Мелатонин и его регулирующее влияние на гормональном, тканевом и клеточном уровнях

З.В. Чумак, Н.В. Шаповал, Г.С. Манасова, Н.Н. Кухар, О.В Жовтенко УО «Одесский национальный медицинский университет»

2017 №2 | Лекции

Аннотация

Список литературы

Проведен анализ ряда работ отечественной и зарубежной литературы, посвященных изучению регуляторного влияния мелатонина на организм. Пока-зана возрастная динамика синтеза мелатонина, определенные механизмы вли-яния на репродуктивную функцию, антиоксидантные и иммуномодулирующие свойства, участие в процессах канцерогенеза, посредством изменения проли-феративной и апоптозной активности, угнетения активности теломеразы.В результате проведенного анализа можно заключить наличие у мелато-нина способности регулировать биологические ритмы, антиоксидантной и противоопухолевой активности, контроля над эндокринной, нервной, иммун-ной системами, способности обеспечивать естественную структуру сна, за-медлять процессы старения, влияния на развитие беременности и плод.

Ключевые слова:

эпифиз, мелатонин, биоритмы, канцерогенез, пролиферация, апоптоз

Melatonin and its regulatory effect on the hormone, tissue and cellular levels

The analysis of a number of works of domestic and foreign literature devoted to the study of regulatory impact on melatonin hormone, tissue and cellular levels. Has been shown age dynamics of the synthesis of melatonin, has been highlighted certain mechanisms of influence on the reproductive function, antioxidant and immunomodu-latory properties. The results of many studies melatonin has confirmed participation in the carcinogenesis process, by changing the proliferative and apoptotic activity, inhibition of telomerase activity.As a result of the carried-out analysis it is possible to conclude existence at mel-atonin of ability to regulate biological rhythms, antioxidatic and antitumoral activity, control over endocrine, nervous, immune systems, ability to provide natural structure of a dream, to slow down processes of aging, influence on development of pregnancy and a fetus.

Keywords

pineal gland, melatonin, biorhythms, carcinogenesis, proliferation, apoptosis

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