In 207 patients with different stages of CKD and 60 individuals in the comparison group, the parameters of the renin-angiotensin-aldosterone system and their relationship with renal function and PTH levels were determined. It was found that patients with CKD are characterized by a tendency towards a lower level of aldosterone in the blood serum, up to the terminal stage of CKD, as well as hyperreninemia in the early stages of CKD and its decrease with the progression of the disease. The highest incidence of hyperaldosteronism was recorded in dialysis and transplant patients. A weak correlation was found between PTH and aldosterone levels in patients with CKD. At the same time, multidirectional changes in the medians of blood concentrations of aldosterone and renin were revealed in subgroups of patients with the presence and absence of SHPT.
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- Поступила 15.11.2021 г.