The article describes a rare clinical case of hemolytic disease of a newborn caused by maternal anti-rh antibodies (E). In the gestation period of 25 weeks, antibodies were detected in a titer of 1: 256. In order to clarify the specificity of antibodies and phenotyping of erythrocytes, a woman was sent to the Hematology and Transfusiology Research Center. The erythrocyte phenotype was established: CcDeekk; antibodies of the Rh anti-rh html5-dom-document-internal-entity2-8243-end (E) system were detected in a titer of 1: 542. In the dynamics was carried out monitoring of antibody titer, an increase in titer was observed. By 32-33 weeks of pregnancy titer was 1: 1024. Currently, the RSPC "Hematology and Transfusiology" uses methods to detect antibodies to erythrocyte antigens and to establish their specificity using identification cards. Due to immuno-hematological monitoring of the pregnant woman, a pathological antibody titer of anti-rh html5-dom-document-internal-entity2-8243-end (E) was detected. The following laboratory examinations were carried out immediately at birth: O (I) Rh positive mother’s blood group and O (I) Rh positive baby (group compatible and rhesus-compatible blood) positive, the cord blood bilirubin level was 134 µmol / L. Complete blood count: Hb = 93 g / l, erythrocytes 2 html5-dom-document-internal-entity2-215-end 1012 / l, leukocytes 23.2 html5-dom-document-internal-entity2-215-end 109 / l, Ht = 29.3%, MSV = 143.6 fl, MCH = 45.6 pg, MCHC = 317 g / dl, platelets 150 html5-dom-document-internal-entity2-215-end 109 / l, normoblasts 446: 100, reticulocytes 40%. The direct Coombs test is positive. In the dynamics of the first two hours of life in a biochemical analysis of the blood of a child, total bilirubin was 179 html5-dom-document-internal-entity2-956-endmol / l, unconjugated bilirubin 164.1 html5-dom-document-internal-entity2-956-endmol / l, hourly increase of bilirubin 15 html5-dom-document-internal-entity2-956-endmol / l / hour. Given the severe course of hemolytic disease in the newborn according to the Rhesus system, the child is shown to have an early replacement blood transfusion at least two times.Phenotyping of erythrocytes of mother and child was carried out. Blood incompatibility by E rhesus antigen was established. With the compatible blood of mother and child, it was possible to carry out laboratory and diagnostic tests at child birth, to make a diagnosis and to conduct pathogenetic therapy in a group and Rh affiliation in time.
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