Отправить статью
EN
Адрес для писем
220006, г. Минск, ул. Ленинградская 6, кабинет 2
Телефон: +375 17 363-88-92
Эл.почта: medjournal@bsmu.by

Влияние психоактивных веществ на когнитивные функции

В. И. Пикиреня, А. В. Копытов УО «Белорусский государственный медицинский университет»
2017 №1 | Лекции
Аннотация
Список литературы
Скачать полнотекстовую статью
В обзоре приведено краткое описание когнитивных функций человека и проведен анализ влияния на них психоактивных веществ: алкоголя, психостимуляторов (амфетамина, кокаина) и опиоидов. Разобраны механизмы действия каждой группы на когнитивные функции. Впервые в русскоязычной литературе описан синдром исполнительского дефицита, развивающийся при длительном злоупотреблении алкоголем. При описании влияния психостимуляторов на когнитивные функции уделено внимание как положительным эффектам, проявляющимся в случаях применения терапевтических доз препаратов, так и отрицательным последствиям злоупотребления. Анализ влияния опиоидов на когнитивную сферу не позволил выявить однозначного стойкого негативного влияния злоупотребления и продемонстрировал относительную безопасность применения опиоидов в терапевтических дозировках, в том числе при управлении автотранспортом.
Ключевые слова:
когнитивные функции, психоактивные вещества, алкоголь, амфетамин, кокаин, опиоиды, синдром исполнительского дефицита, когнитивные нарушения
The impact of psychoactive substances on cognitive functions

In the survey there is given a description of human cognitive functions and there has been held the analysis of influence of psychoactive on them: the influence of alcohol, psychostimulants and opioids. There were studied out the mechanisms of influence of each group on cognitive functions. For the first time in a russian-language literature there has been described the dysexecutive syndrome, as a result of a long-term alcohol abuse. While describing the influence of the psychostimulants the attention was paid either to their positive effects after a therapeutic use of the substances and the negative outcomes of the abuse. The analysis of the opioid influence on the cognitive sphere didn’t show any decisive and a rigid negative impact of the abuse and the use of opioids in therapeutic doses was considered relatively safe, as well driving the vehicle.

Keywords
cognitive functions, psychoactive substances, alcohol, amphetamine, cocaine, opioids, dysexecutive syndrome, cognitive impairment
  • 1. Винницкая, А. Г. Оценка численности инъекционных потребителей наркотиков в Беларуси с использованием метода повторного захвата / А. Г. Винницкая, Ю. Е. Разводовский, В. В. Лелевич // Вопросы наркологии. - 2011. - № 5. - C. 46 - 50.
  • 2. Atkinson, R. C. Human memory: A proposed system and its control processes / R. C. Atkinson, R. M. Shiffrin/ - New York: Academic Press, 1968. - P. 89-195.
  • 3. Baddeley, A. Frontal amnesia and the dysexecutive syndrome / A. Baddeley, B. Wilson // Brain and cognition. - 1988. - № 2 (7). - P. 212-30.
  • 4. Ballard, M. E. Amphetamine increases errors during episodic memory retrieval / M. E. Ballard, D. A. Gallo, H. Wit // Jornal of Clinical Psychopharmacol. - 2014. - № 1 (34). - P. 85 - 92.
  • 5. Barch, D. M. Amphetamine improves cognitive function in medicated individuals with schizophrenia and in healthy volunteers/ D. M. Barch, C. S. Carter // Schizophrenia research. - 2005. - № 1 (77). - P. 43-58.
  • 6. Bates, M. E. Short-term neuropsychological recovery in clients with substance use disorders / M. E. Bates // Alcoholism, clinical and experimental research. - 2005. - № 3 (29). - P. 367-77.
  • 7. Bernardin, F. Cognitive impairments in alcoholdependent subjects / F. Bernardin, A. Maheut-Bosser, F. Paille// Frontiers in Psychiatry. - 2014. - № 78 (5). - P. 1 - 6.
  • 8. Billman, G. E. Cocaine: a review of its toxic actions on cardiac function / G. E. Billman // Critical reviews in toxicology. - 1995. - № 2 (25). - P. 113-32.
  • 9. Britton, A. Alcohol consumption and cognitive function in the Whitehall II Study / A. Britton, A. Singh-Manoux, M. Marmot // American journal of epidemiology. - 2004. - № 3 (160). - P. 240-247.
  • 10. Burgess, P. W. Theories of frontal lobe executive function: clinical applications / P. W. Burgess, J. S. Simons // Oxford University Press, 2005. - P. 211-231.
  • 11. Collins, A. Reasoning, learning, and creativity: frontal lobe function and human decision-making / A. Collins, E. Koechlin // PLoS biology. - 2012. - № 3 (10). - P. e1001293.
  • 12. Davies, I. J. Benzedrine: Uses and Abuses: (Section of Medicine with the Section of Therapeutics and Pharmacology) / I. J. Davies // Proceedings of the Royal Society of Medicine. - 1939. - № 4 (32). - P. 3 8 5 - 9 8.
  • 13. Ersek, M. The cognitive effects of opioids / M. Ersek // Pain Management Nursing. - 2004. - № 2 (5). - P. 7 5 - 9 3.
  • 14. Fishbain, D. A. Are Opioid-Dependent / Tolerant Patients Impaired in Driving-Related Skills? A Structured Evidence-Based Review / D. A. Fishbain // Journal of Pain and Symptom Management. - 2003. - № 6 (25). - P. 559-577.
  • 15. Friswell, J. Acute effects of opioids on memory functions of healthy men and women / J. Friswell // Psychopharmacology. - 2008. - № 2 (198). - P. 243-250.
  • 16. Getahun, D. Recent trends in childhood attentiondeficit/hyperactivity disorder / D. Getahun // JAMA pediatrics. - 2013. - № 3 (167). - P. 2 8 2 - 8.
  • 17. Homer, B. D. Methamphetamine Abuse and Impairment of Social Functioning: A Review of the Underlying Neurophysiological Causes and Behavioral Implications / B. D. Homer // Psychological Bulletin. - 2008. - № 2 (134). - P. 301-310.
  • 18. Ihara, H. Group and case study of the dysexecutive syndrome in alcoholism without amnesia / H. Ihara, G. E. Berrios, M. London // Journal of neurology, neurosurgery, and psychiatry. - 2000. - № 6 (68). - P. 731-7.
  • 19. Jamal, M. Catalase mediates acetaldehyde formation in the striatum of free-moving rats / M. Jamal // Neurotoxicology. - 2007. - № 6 (28). - P. 1 2 4 5 - 8.
  • 20. Jovanovski, D. Neurocognitive deficits in cocaine users: a quantitative review of the evidence / D. Jovanovski, S. Erb, K. K. Zakzanis // Journal of clinical and experimental neuropsychology. - 2005. - № 2 (27). - P. 189-204.
  • 21. Kamboj, S. K. The effects of immediate-release morphine on cognitive functioning in patients receiving chronic opioid therapy in palliative care / S. K. Kamboj // Pain. - 2005. - № 3 (117). - P. 3 8 8 - 3 9 5.
  • 22. Kosten, T. R. The neurobiology of opioid dependence: implications for treatment / T. R. Kosten, T. P. George // Science & practice perspectives / a publication of the National Institute on Drug Abuse, National Institutes of Health. - 2002. - № 1 (1). - P. 13-20.
  • 23. Lawlor, P. G. The panorama of opioid-related cognitive dysfunction in patients with cancer: A critical literature appraisal / P. G. Lawlor // Cancer. - 2002. - № 6 (94). - P. 1836-1853.
  • 24. Liao, D.-L. Cognitive control in opioid dependence and methadone maintenance treatment / D.-L. Liao // PloS one. - 2014. - № 4 (9). - P. e94589.
  • 25. Magnan, J. The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties / J. Magnan // Naunyn-Schmiedeberg's Archives of Pharmacology. - 1982. - № 3 (319). - P. 197-205.
  • 26. Mattay, V. S. Effects of Dextroamphetamine on Cognitive Performance and Cortical Activation / V. S. Mattay // NeuroImage. - 2000. - № 3 (12). - P. 268-275.
  • 27. Morrow, S. A. The effects of L-amphetamine sulfate on cognition in MS patients: results of a randomized controlled trial / S. A. Morrow // Journal of neurology. - 2009. - № 7 (256). - P. 1095-102.
  • 28. Ornstein, T. J. Profiles of Cognitive Dysfunction in Chronic Amphetamine and Heroin Abusers / T. J. Ornstein // Neuropsychopharmacology. - 2000. - № 2 (23). - P. 113-126.
  • 29. Peng, G.-S. Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations / G.-S. Peng, S.-J. Yin // Human genomics. - 2009. - № 2 (3). - P. 121-127.
  • 30. Pietschmann, T. A century of international drug control / T. Pietschmann // Bulletin on Narcotics. -2007. - № 1 - 2 (59). - P. 1-167.
  • 31. Potvin, S. Cocaine and cognition: a systematic quantitative review / S. Potvin // Journal of addiction medicine. - 2014. - № 5 (8). - P. 368-76.
  • 32. Quertemont, E. Role of acetaldehyde in mediating the pharmacological and behavioral effects of alcohol / E. Quertemont, V. Didone // Alcohol research & health: the journal of the National Institute on Alcohol Abuse and Alcoholism. - 2006. - № 4 (29). - P. 258-265.
  • 33. Rippeth, J. D. [etal.]. Methamphetamine dependence increases risk of neuropsychological impairment in HIV infected persons // Journal of the International Neuropsychological Society: J INS. - 2004. - № 1 (10). - P. 1-14.
  • 34. Robertson, S. D. A closer look at amphetamineinduced reverse transport and trafficking of the dopamine and norepinephrine transporters / S. D. Robertson, H. J. G. Matthies, A. Galli // Molecular neurobiology. - 2009. - № 2 (39). - P. 7 3 - 8 0.
  • 35. Rothman, R. B. Amphetamine-Type Central Nervous Norepinephrine More Potently Than They Release Dopamine and Serotonin / R. B. Rothman // Synapse. - 2001. - № March 2000 (39). - P. 3 2 - 4 1 .
  • 36. Sargant, W. The effect of benzedrine on intelligence scores / W. Sargant, J. M. Blackburn // The Lancet. - 1936. - № 5911 (228). - P. 1385-1387.
  • 37. Scott, J. C. Neurocognitive effects of methamphetamine: a critical review and meta-analysis / J. C. Scott // Neuropsychology review. - 2007. - № 3 (17). -P. 275-97.
  • 38. Simon, S. L. The effect of relapse on cognition in abstinent methamphetamine abusers / S. L. Simon // Journal of Substance Abuse Treatment. - 2004. -№ 1 (27). - P. 5 9 - 6 6 .
  • 39. Strassels, S. A. Cognitive effects of opioids / S. A. Strassels // Current Pain and Headache Reports. - 2008. - № 1 (12). - P. 3 2 - 3 6.
  • 40. Sutton, J. Memory / J. Sutton // The Stanford Encyclopedia of Philosophy. - 2012. - 242 p.
  • 41. Unated Nations, Report of the International Narcotics Control Board for 2013. - New York, 2015.
  • 42. UNODC World Drug Report, 2014.
  • 43. Vabret, F. Alcohol-related neuropsychological impairments: Nature, impact and detection / F. Vabret, // Presse medicale. - 2016. - May. - P. 9.
  • 44. Volkow, N. D. Decreased dopamine D 2 receptor availability is associated with reduced frontal metabolism in cocaine abusers / N. D. Volkow // Synapse. - 1993. - № 2 (14). - P. 169-177.
  • 45. Walker-Batson, D. A Double-Blind, Placebo-Controlled Study of the Use of Amphetamine in the Treatment of Aphasia Editorial Comment / D. Walker-Batson // Stroke. - 2001. - № 9 (32). - P. 2093-2098.
  • 46. Zimatkin, S. M. Enzymatic mechanisms of ethanol oxidation in the brain / S. M. Zimatkin // Alcoholism, clinical and experimental research. - 2006. - № 9 (30). - P. 1500-1505.