Особенности течения беременности при аллельном полиморфизме -174 G/C промоторной области гена интерлейкина 6

М. С. Недосейкина, Е. А. Аксенова, Е. И. Барановская УО «Гомельский государственный медицинский университет», ГНУ «Институт цитологии и генетики НАН Беларуси», УО «Белорусский государственный медицинский университет»

2014 №4 | Оригинальные научные публикации

Аннотация

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Целью данного исследования было выявление предрасположенности к развитию инфекционно-обусловленных осложнений беременности. Обследовано 100 женщин в третьем триместре беременности, среди которых было 50 пациенток с преждевременными родами и 50 женщин со срочными родами.

Ключевые слова:

полиморфизм генов, интерлейкин 6, инфекционно-обусловленные осложнения беременности, преждевременные роды

Features of pregnancy in women with polymorphism -174 G/C gene promoter region of interleukin-6

The aim of this study was to investigate the relationship between single nucleotide polymorphisms (SNP) of the interleukin 6 gene promoter (-174G/C) and complications of pregnancy. In the study was involved 100 women in the third trimester of pregnancy, which included 50 patients with preterm labor and 50 women with term births. The DNA was extracted and SNP in the human IL-6 gene at positions -174 (G/C), respectively, was analyzed using the polymerase chain reactionrestriction fragment length polymorphism method. In patients with genotype of IL-6 (-174GC), we found a high incidence of cervical infections (22,9%; p = 0,003) and chronic compensated tonsillitis before the current pregnancy (58,3%; P = 0,0004). In the group with genotype IL-6 (-174CC) was observed a greater frequency of threatened abortion, vaginitis, preterm premature rupture of membranes and intrauterine growth restriction, preterm birth’ rate was 75%.

Keywords

single nucleotide polymorphisms, interleukin 6, complications of the pregnancy, preterm labor

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