А. Т. Быков, А. В. Шапошников, Т. Н. Маляренко
УО «Кубанский государственный медицинский университет», УО «Ростовский научно-исследовательский онкологический институт»
В последнее время быстро нарастает интерес исследователей и клиницистов к роли кишечной микробиоты в поддержании здоровья человека,а также в развитии и предупреждении ряда заболеваний. Установлено, что гомеостаз кишечной микробиоты способствует нормальному функционированию различных систем организма. Нарушение равновесия в кишечной экосистеме (дизбиоз) ассоциируется со многими патологическими процессами, включая аутоиммунные, метаболические и злокачественные заболевания. В настоящем обзоре обобщены не только данные о последствиях дизбиоза кишечника для органов и функций по оси «кишечник-микробиота-мозг-хозяин», но и представлены пути профилактики и коррекции нарушений состава микробиоты и улучшения здоровья человека при использовании пребиотиков, пробиотиков и ряда нутриентов и диет.
ключевые слова: микробиота кишечника, здоровье человека, последствия дизбиоза, профилактика, диетическая коррекция микробиоты
Gut microbiota: its implications in human health, development and prevention of specific diseases
A. T. Bykov, A. V. Shaposhnikov, T. N. Malyarenko
Last time it is notes the rapid increase in interest to the role of gut microbiota in support of human health and in development and prevention some disease as consequences of dysbiosis. It was found that gut microbiota homeostasis supports not only functions of gastrointestinal tract but many functional systems of whole organism. Some prolonged disorders of gut microbiota composition can initiate, particularly, metabolic syndrome, obesity-related diseases, liver, bowel diseases, vary forms of malignisation, and contribute other disorders in various organs and functions on the complex axis “gut-microbiota-brain-host”. There are reviewed the impact of environmental factors including aspects of diet and life style on the gut microbiota and different potential therapies, such as correction of diet, using prebiotics, probiotics and some nutrients aimed at modulation of the put microbiota for improving human health in whole.
keywords: gut microbiota, human health, consequences of dysbiosis, prevention, dietic correction
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