Оценка факторов риска прогрессирования вторичныx гломерулопатий у детей

И. А. Козыро, А. В. Сукало, А. П. Мириленко УО «Белорусский государственный медицинский университет», УО «Белорусский государственный аграрный технический университет»

2021 №2 | Оригинальные научные публикации

Аннотация

Список литературы

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Проблема гломерулярного повреждения почек остается актуальной в педиатрической нефрологии в связи с многообразием причин ее развития, склонностью к прогрессированию. По данным Белорусского Центра детской нефрологии и почечной заместительной терапии в структуре причин терминальной стадии хронической болезни почек (ХБП) гломерулопатии (ГП) занимают 2-ое место. Особенности течения ГП диктуют необходимость поиска информативных предикторов риска развития неблагоприятных событий, которые позволят с высокой степенью вероятности прогнозировать и проводить профилактику почечного повреждения. Цель исследования: определение скорости прогрессирования вторичных хронических ГП у детей и установление основных факторов риска развития этого процесса.

Ключевые слова:

гломерулопатии, прогрессирование, дети

Assessment of risk factors for progression of secondary glomerupathies in children

The problem of glomerular kidney damage remains relevant in pediatric nephrology due to the variety of reasons for its development and tendency to progression. According to the data of the Belarusian Center for Pediatric Nephrology and Renal Replacement Therapy, glomerulopathies (GP) occupy 2nd place in the structure of the causes of end-stage chronic kidney disease (CKD). The peculiarities of the course of GP dictate the need to search for informative predictors of the risk of adverse events, which will predict and prevent renal damage with a high degree of probability. Purpose of the study: to determine the rate of progression of secondary GP in children and to establish the main risk factors for its development.

Keywords

glomerulopathies, progression, children

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References
1. Wong, C. J., MoxeyMims M., JerryFluker J., Warady B. A., Furth S. L. CKiD (CKD in children) prospective cohort study: a review of current findings // Am J Kidney Dis. – 2012. – Vol. 60(6). – P. 1002–11. doi: 10.1053/j.ajkd.2012.07.018. Epub 2012 Sep 28.
2. Wong, C. S., Pierce C. B., Cole S. R., Warady B. A., Mak R. H., Benador N. M., Kaskel F., Furth S. L., Schwartz G. J. CKiD Investigators. Association of proteinuria with race, cause of chronic kidney disease, and glomerular filtration rate in the chronic kidney disease in children study // Clin. J. Am Soc Nephrol. – 2009. – № 4(4). – P. 812–9. doi: 10.2215/CJN.01780408. Epub 2009 Mar 18.
3. Winnicki, E., McCulloch C. E., Mitsnefes M. M., Furth S. L., Warady B. A., Ku E. Use of the Kidney Failure Risk Equation to Determine the Risk of Progression to Endstage Renal Disease in Children With Chronic Kidney Disease // JAMA Pediatr. – 2018. – Vol. 172(2). – P. 174–180. doi: 10.1001/jamapediatrics. 2017.4083.
4. Webb, N. J., Shahinfar S., Wells T. G., Massaad R., Gleim G. W., Santoro E. P., Sisk C. M., Lam C. Losartan and enalapril are comparable in reducing proteinuria in children // Kidney Int. – 2012. – Vol. 82(7). – P. 819–26. doi: 10.1038/ki.2012.210. Epub 2012 Jun 27.
5. Warady, B. A., Abraham A. G., Schwartz G. J., Wong C. S., Muñoz A., Betoko A., Mitsnefes M., Kaskel F., Greenbaum L. A., Mak R. H., Flynn J., MoxeyMims M. M., Furth S. Predictors of Rapid Progression of Glomerular and Nonglomerular Kidney Disease in Children and Adolescents: The Chronic Kidney Disease in Children (CKiD) Cohort // Am J Kidney Dis. – 2015. – Vol. 65(6). – P. 878–88. doi: 10.1053/j.ajkd.2015.01.008. Epub 2015 Mar 19.
6. van Biljon, I., Meyers A. M. Paediatric chronic kidney disease // S Afr Med J. – 2015. – Vol. 105(4). – P. 316–9. doi: 10.7196/samj.9532.
7. Uemura, O., Ishikura K., Kaneko T., Hirano D., Hamasaki Y., Ogura M., Mikami N., Gotoh Y., Sahashi T., Fujita N., Yamamoto M., Hibino S., Nakano M., Wakano Y., Honda M. Perinatal factors contributing to chronic kidney disease in a cohort of Japanese children with very low birth weight // Pediatr Nephrol. – 2020. – Oct 17. doi: 10.1007/s00467020047911. Online ahead of print.
8. Uwaezuoke, S. N., Ayuk A. C., Muoneke V. U., Mbanefo N. R. Chronic kidney disease in children: Using novel biomarkers as predictors of disease // Saudi J Kidney Dis Transpl. – 2018. – Vol. 29(4). – P. 775–784. doi: 10.4103/13192442.239657.
9. Stritzke, A., Thomas S., Amin H., Fusch C., Lodha A. Renal consequences of preterm birth // Mol Cell Pediatr. – 2017. – № 4(1). – Р. 2. doi: 10.1186/s4034801600680. Epub 2017 Jan 18.
10. Staples, A., Wong C. Risk factors for progression of chronic kidney disease // Curr Opin Pediatr. 2010 Apr;22(2):161–9. doi: 10.1097/MOP.0b013e328336ebb0.
11. Stern-Zimmer, M., CalderonMargalit R., Skorecki K., Vivante A. Childhood risk factors for adulthood chronic kidney disease // Pediatr Nephrol. – 2020. – Jun 4. doi: 10.1007/s00467020046116. Online ahead of print.
12. Staples, A. O., Greenbaum L. A., Smith J. M., Gipson D. S., Filler G., Warady B. A., Martz K., Wong C. S. Association between clinical risk factors and progression of chronic kidney disease in children // Clin J Am Soc Nephrol. – 2010. – Vol. 5(12). – P. 2172–9. doi: 10.2215/CJN.07851109. Epub 2010 Sep 2.