Diffusion lung capacity shows the function of the gas exchange lung zone. Disorders leading to a decrease in the diffusion surface area or an increase in its thickness result in a decrease in oxygen diffusion through the alveolar-capillary membrane. The objective of the study was to assess the peculiarities of diffusion lung capacity in patients with rheumatoid arthritis depending on the clinical, laboratory and immunological indicators. The study involved 58 patients with rheumatoid arthritis: 28 men and 30 women. The interview considered their past medical history and respiratory complaints. The x-ray stage of rheumatoid arthritis was determined, as well as the disease activity score DAS28. Complete blood count and blood chemistry were taken. The Chlamydophila pneumoniae infection markers were studied. Diffusion lung capacity was tested. A decrease in diffusion lung capacity was observed 4,8 times more frequently in the patients with rheumatoid arthritis and elbow joints involvement. A decrease in diffusion lung capacity in the patients with rheumatoid arthritis had no link to the laboratory activity of the disease, however, it correlated with the high rate of anti-citrullinated protein antibodies. Presumably, the lungs actively participate in the immune response to rheumatoid arthritis, particularly in the synthesis of anti-citrullinated protein antibodies. A diffusion lung capacity decrease may indicate the high rate of humoral immune response in patients with rheumatoid arthritis.
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