There are rare diseases with skin lesions, characterized by the presence of vesiculo-bullous rashes. Vesicles and bullae in the newborn may be caused by infections, congenital disorders, or other diseases. This article examines vesiculo-bullous eruptions caused by infections, and congenital/inherited bullous diseases presenting in the newborn are reviewed here. Clinical features of diseases that occur with vesicular rash in newborns are presented. Issues of differential diagnosis of infectious and non-infectious genesis of skin lesions in children in the neonatal period are discussed. Attention is paid to additional methods of examination in children to clarify the diagnosis. Careful identification and detailed description of morphological elements leads to timely correct diagnosis of diseases in children.
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