Влияние кишечной микробиоты, пребиотиков и пробиотиков на кости

А.Т. Быков, Т.Н. Маляренко УО «Кубанский государственный медицинский университет», г. Краснодар, РФ

2018 №1 | Лекции

Аннотация

Список литературы

Представленные в обзоре данные демонстрируют роль кишечной микробиоты в регуляции баланса остеокластов и остеобластов в костной ткани, в повышении прочности костей. Во многих исследованиях установлено, что дополнительное поступление в кишечник пребиотиков и пробиотиков может влиять на метаболизм кальция и состояние костной ткани.

Ключевые слова:

кишечная микробиота, пребиотики, пробиотики, профилактика нарушений структуры и прочности костей

The impact of gut microbiota, prebiotics and probiotics on bones state

The data of this review demonstrate the role of intestinal microbiota in the regulation of the balance of osteoclasts and osteoblasts in bone tissue, increase bones strength. Many studies have shown that additional supply prebiotics and probiotics to the intestines can affect calcium metabo-lism and bones structure.

Keywords

gut microbiota, prebiotics, probiotics, prevention of bones structure and state disorders

1. Быков А.Т., Шапошников А.В., Маляренко Т.Н. Микробиота кишечника: вклад в здоровье, развитие и профилактику заболеваний человека // Мед. Журн. – 2017. – № 4.
2. Abrams S.A., Griffin I.J., Hawthorne K.M., et al. A combination of prebiotic short-and long chain inulintype fructans enhances calcium absorption and bone mineralization in young adolescents // Am. J. Clin. Nutr. – 2005. – Vol. 82. – P. 471-476.
3. Amdekar S., Singh V., Singh R., et al. Lactobacillus casei reduces the inflammatory joint damage associated with collagen-induced arthritis (GIA) by reducing the proinflammatory cytokines: Lactobacillus casei: COX-2 inhibitor // J. Clin. Immunol. – 2011. – Vol. 31. – P. 147-154.
4. Aubin G.G., Baud’huin M., Lavigne J.-Ph., et al. Interaction of Cutibacterium (formerly Propionibacterium) acnes with bone cells: a step toward understanding bone and joint infection development // Sci. Rep. ‒ 2017. – Vol. 7. – Article 42918.
5. Avella M.A., Place A., Du S-J., et al. Lactobacillus rhamnosus accelerates zebrafish backbone calcification and gonadal differentiation through effects on the GnRH and IGF systems // PloS one. – 2012. – Vol. 7. – e45572.
6. Backhed F., Fraser C.M., Ringel Y., et al. Defining a healthy human gut microbiome: current concepts, future directions, and clinical applications // Cell Host. Microbe. – 2012. – Vol. 12. – P. 611-622.
7. Bindels L.B., Delzenne N.M., Cani P.D., Walter J. Towards a more comprehensive concept for prebiotics // Nat. Rev. Gastroenterol. Hepatol. – 2015. – Vol. 1gnesium and 2. – P. 303-310.
8. Britton R.A., Irwin R., Quach D., et al. Probiotic L. reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model // J. Cellular Physiol. - 2014. – Vol. 229. – P. 1822-1830.
9. Bryk G., Coronel M.Z., Pellegrini G., et al. Effect of combination GOS/FOS prebiotic mixture and interaction with calcium intake on mineral absorption and bone parameters in growing rats // Euro. J. Nutr. – 2014. - …
10. Foureaux R.d.C., Messora M.R., de Oliveira L.F.F., et al. Effects of probiotic therapy on metabolic and inflammatory parameters of rats with ligature-induced periodontites associated with restraint stress // J. Periodontology. – 2014. – Vol. 85. – P. 975-983.
11. Garcia-Vieyra M.I., Del Real A., Lopez M.G. Agave fructans: their effect on mineral absorbtion and bone mineral content // J. Med. Food. – 2014. – Vol. 17. – P. 1247-1255.
12. Garcia V.G., Knoll L.R., Longo M., et al. Effect of the probiotic Saccharomyces cerevisiae on ligature-induced periodontitis in rats // J. Periodontal Research. – 2015. – n/a-n/a. [PubMed].
13. Hoelster H.D., Caporaseo J.G., Hooda S., et al. Fiber supplementation influences phylogenetic structure and functional capacity of the human intestinal microbiome: follow-up of a randomized controlled trial // Am. J. Clin. Nutr. – 2014. – doi: 10.3495/ajcn.114.092064.
14. Holloway L., Moynihan S., Abrams S.A., et al. Effects of oligofructose-enriched inulin on intestinal absorption of calcium and magnesium and bone turnover markers in postmenopausal women //Br. J. Nutr. – 2007. – Vol.97. – P. 365-372.
15. Human Microbiome Project C. Structure, function and diversity of the healthy human microbiome // Nature. – 2012. – Vol. 486. – P. 207-212.
16. Irwin R., Lee T., Young V.B., et al. Colitis induced bone loss is gender dependent and as-sociated with increased inflammation // Inflamm. Bowel Dis. – 2013. – Vol. 19. – P. 1586-1597.
17. Kudo O., Fudjirawa Y., Itonaga I., et al. Proinflammatory cytokine (TNFalfa / IL-1alfa) induction of human osteoclast formation // J. Pathol. – 2002. – Vol. 198. – P. 220-227.
18. Langlands S.J., Hopkins M.J., Coleman N., Cummings J.H. Prebiotic carbohydratis modify the mucosa associated microflora of the human large bowel // Gut. – 2004. – Vol. 53. – P. 1610-1616.
19. McCabe L., Britton R.A., Parameswaran N. Prebiotic and probiotic regulation of bone health: role of intestine and its microbiome // Curr. Osteoporos Rep. – 2015 Dec. – Vol. 13. – No. 6. – P. 363-371.
20. McCabe L., Irwin R., Shaefer L., Britton R.A. Probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice // J. Cellular Physiol. - 2013. – Vol. 228. – P. 1793-1798.
21. O’Hara A.M., Shanahan F. The gut flora as a forgotten organ // EMBO Rep. - 2006. – No. 7. – P. 688-693.
22. Park C.Y., Weaver C.M. Calcium and bone health: influence of prebiotics // Funct. Food Rev. - 2011. – No. 3. – P. – 62-72.
23. Parvaneh K. Probiotic (Bifidobacterium longum) increases bone mass density and upregulates Sparc and Bmp-2 genes in rats with bone loss resulting from ovariectomy // BioMed Research Intern. - 2015. – Vol. 2015. – Art. ID 897639. – 10 p.
24. Roberfroid M., Gibson G.R., Hoyles L., et al. Prebiotic effects: metabolic and health benefits // Br. J. Nutr. – 2010. – Vol. 104. – Suppl. 2. – S1-63.
25. Rodrigues F.C., Castro A.S.B., Rodrigues V.C., et al. Yacon flour and Bifidobacterium longum modulate bone health in rats // J.Med.Food. – 2012. – Vol. 15. – P. 664-677.
26. Scholz-Ahrens K.E., Ade P., Marten B., et al. Prebiotics, probiotics, and synbiotics affect mineral absorbtion, bone mineral content, and bone structure // J. Nutr. – 2007. – Vol. 137. – P. 838S-846S.
27. Slevin M.M., Allsopp P.J., Magee P.J., et al. Supplementation with calcium and short-chain fructo-oligosaccharides affects markers of bone turnover but not bone mineral density in postmenopausal women // J. Nutr. - 2014. –Vol. 144. – P. 297-304.
28. Sjӧgren K., Endhal C., Henning P., et al. The gut microbiota regulates bone mass in mice // J. Bone Miner. Res. – 2012. – Vol. 27. – P. 1357-1367.
29. Steves C., Bird S., Williams F.M.K., Spector T.D. The microbiome and musculoskelenal conditions of aging: a review of evidence for impact and potential therapeutics // J. Bone a. Mineral research. – 2016. – Vol. 31. – Issue 2. – P. 261-269.
30. Varley P.F., McCarney C., Callan J.J., et al. Effect of dietary mineral level and inulin inclusion on phosphorus, calcium and nitrogen utilization, intestinal microflora and bone development // J. Sci. Food Agric. - 2010. – Vol.90. – P. 2447-2454.
31. Wallace T.C., Marzorati M., Spence L., et al. New frontiers in fibers: innovative and emerging research on the gut microbiome and bone health // J. Am. Coll. Nutr. – 2017 Mar.-Apr. – Vol. 36. – No. 3. – P. 218-222.
32. Weaver C.M. Calcium supplementation: is protecting against osteoporosis counter to protecting against cardiovascular disease // Curr. Osteoporos. Rep. – 2014. – No.12. - P. 211- 218.
33. Weaver C.M. Diet, gut microbiome, and bone health // Curr Osteoporos Rep. – 2015. – Vol. 13. – P. 125-130.
34. Weaver C.M., Martin B.R., Story J.A., et al. Novel fibers increase bone calcium content and strength beyond efficiency of large intenstine fermentation // J. Agric. Food Chem. – 2010. – Vol. 58. – P. 8952-8957.
35. Whisner C.M., Martin B.R., Nakatsu C.H. Soluble maize fibre affectsshort-term calcium absorption in adolescent boys and girls: a randomized controlled trial using dual stable isotopic tracers // Br. J. Nutr. – 2014. - Vol. 112. – P. 446-456.
36. Whisner C.M., Martin B.R., Schoterman M.H.C., et al. Galacto-oligosaccharides increase calcium absorption and gut bifidobacteria in young girls: a double blind crossover trial // Br. J. Nutr. – 2013. - Vol. 110. – P. 1292-1303.
37. Whisner C.M., Weaver C.M. Interactions of probiotics and prebiotics with minerals / In: Probiotics and prebiotics in food, nutrition and health (ed. Semih Ötles). – CRC Press; Boca Rotan FL. – 2013. – P. 200-231.
38. Zhang J., Motyl K.J., Irwin R., et al. Loss of bone and Wnt10b expression in male type I diabetic mice is blocked by probiotic L. reuteri // Endocrinology. – 2015. – EN20151308. Поступила 17.11.2017 г.