Заболевания печени: патогенетическая и гепатопротекторная роль кишечной микробиоты

А.Т. Быков, Ю.М. Амбалов, Т.Н. Маляренко УО «Кубанский государственный медицинский университет», УО «Ростовский государственный медицинский университет»

2017 №4 | Лекции

Аннотация

Список литературы

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В обзоре продемонстрировано, что мировая литература последних лет обогатилась новыми знаниями о роли кишечной микробиоты в развитии неалкогольных хронических заболеваний печени и защите от них. Установлено, что микробиота необходима для поддержания гомеостаза печени при её хронических повреждениях, а низкий базальный уровень бактериальных продуктов делает невозможным включение механизмов защиты печени от токсических факторов.

Ключевые слова:

неалкогольные хронические заболевания печени, ось ‘кишечник-печень’, кишечная микробиота, дисбиоз, бактериальная транслокация, превентивные стратегии

Liver diseases: pathogenetic and hepatoprotective role of gut microbiota

The review demonstrates that the world literature of recent years has been enriched with new knowledge about the role of intestinal microbiota in the development of non-alcoholic chronic liver diseases and protection from them. It has been established, that a microbiota is necessary to maintain the liver homeostasis during its damage, and a low basal level of bacterial products makes it impossible to incorporate protective mechanisms against toxic factors.

Keywords

nonalcoholic chronic liver diseases, gut-liver axis, gut microbiota, dysbiosis, bacterial translocation, preventive strategies

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