Индивидуальная эффективность и универсальность действий фармакологических модуляторов Nox2-зависимой генерации АФК

Н. А. Бизунок УО «Белорусский государственный медицинский университет»

2016 №1 | Лекции

Аннотация

Список литературы

В статье проанализирована эффективность существующих подходов к фармакологическому управлению клеточной генерацией активных форм кислорода (АФК), ассоциированной с активностью фермента Nox2-НАД(Ф)Н-оксидазы (E. C. 1.6.3.1), включая действие природных и синтетических антиоксидантов, модуляторов клеточных функций разного типа действия (модификаторы ионных токов, ингибиторы протеинкиназы С, агонисты 7-TMS рецепторов макрофагов, аминокислоты и метаботропные соединения), а также их комбинаций. Изложены перспективные направления разработки проблемы, а также основные результаты работы автора, актуальные не только с позиций фундаментальной науки (теория плейотропного действия лекарственных средств), но и с позиций практического приложения в виде вклада в разработку новых комбинированных лекарственных средств («Тетракард», «Лейаргунал», «Аспаргит», «Инокардин», «Гроцепрол»), внедренных в медицинскую практику и предназначенных для лечения ряда заболеваний, ассоциированных с оксидантным стрессом.

Ключевые слова:

Nox2-НАД(Ф)Н-оксидазы, обзор, антиоксиданты, модуляторы клеточных функций, теория плейотропного действия лекарственных средств, комбинированные лекарственные средства

Pharmacological modulators of Nox2-dependent ROS generation: from the individual to the universal regularities efficiency action

The article analyzes the effectiveness of existing approaches to pharmacological management cell generation of reactive oxygen species (ROS) associated with the activity of the enzyme Nox2-NAD (P) H oxidase (EC 1.6.3.1), including the effect of natural and synthetic antioxidants, modulators of cellular functions of different types action (modifiers of ionic currents, protein kinase C inhibitors, agonists-7 TMS receptor of macrophages and metabotropic amino acid compound)), and combinations thereof. Outlined promising areas of development issues, as well as the main results of the author, is important not only from the standpoint of fundamental science (the theory of the pleiotropic effects of drugs), but also from the standpoint of practical application in the form of a contribution to the development of new combination drugs («Tetrakard», «Leyargunal», «Aspargit», «Inokardin», «Grotseprol») embedded in the practice of medicine for the treatment of a number of diseases associated with oxidative stress.

Keywords

Nox2-NAD(P)H oxidase, review, antioxidants, modulators of cellular functions theory of drugs pleiotropic actions, drug combinations

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