The article is devoted to the currently searching for the new biologically active compounds including seko steroids. First sekosteroids were derived in 1970–80. But so far, there haven’t been reviews on the natural sekosteroids exstractions except vitamins D. Natural seco steroids are of considerable interest due to the wide spectrum of their biological activity. The exstraction process of marine organisms is very time-consuming and often gives small amounts of steroids and metabolites. It enables to establish the unique structures of the natural substances. Establishing of unique structures of this class compounds helps to understand the steroids biosynthesis mechanisms and their subsequent conversion better.
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