Аннотация
Список литературы
Хронический вирусный гепатит В имеет широкое распространение как в мире, так и в Республике Беларусь. К сожалению, течение заболевания можно спрогнозировать, т. к. в исходезаболевания часто развивается цирроз печени, с возможностью появления гепатоцеллюлярной карциномы.
Ключевые слова:
вирусный гепатит В, вакцинация, мутации HBV, противовирусная терапия
The practical application of some theoretical aspects. HBV-infection
Chronic viral hepatitis B is widespread both in the world and in the Republic of Belarus. Unfortunately, the disease can be predicted as in the outcome of the disease often develops cirrhosis of the liver, with the possibility of occurrence of hepatocellular carcinoma. Currently, many different HBV genome research, as well as several of the mutations, in connection with the impact on the quality of vaccination against HBV, the effectiveness of antiviral therapy, because identification of resistance to antiviral drugs to adjust therapy of HBV-infection before her initiation.
Keywords
viral hepatitis B, mutations of HBV, vaccination, antiviral therapy
- 1. Custer, B., Sull ivan S. D., Hazlet T. K., Iloe je U., Vee nstra D. L., Kowdle y K. V. Glo bal ep idemiolo gy of hepat itis B virus // J. Clin. Ga stroe nterol . – 2004. – N 38 (Suppl . 10). – P. 158–168.
- 2. McMahon, B. J. Epidemiolo gy and nat ural histor y of hepat itis B // Semin. Liver Dis. – 2005. – Vol . 25 (Supp . 1). – P. 3–8.
- 3. Tran, T. T. H., Trinh T. N., Abe K. New co mple x reco mbinant genot ype of hepat itis B virus identified in Viet nam. // Journal of virolo gy. – 2008. – Vol . 82, N 11 . – P. 5657–5663.
- 4. Grandjacques, C, Pra dat P, Stuyver L. et al Rap id detect ion of genot ype s and mutat ion in the pre -core pro moter and the pre -core re gion of hepat itis B virus genome: correlat ion with viral per siste nce and disea se sever ity // J. Hepatol . – 2000. – N 33(3). – P. 430–439.
- 5. Schildgen, O., Sirma H, Funk A, et al . Var iant of hepat it is B virus with pr imar y re sista nce to adefovir. N. Engl J med 2006; 354:1807–12.
- 6. Kobavashi, M, Suzuki F, Akuta N. et al . Response to long-term lamivudine treat ment in pat ients infecte d with hepat itis B virus genotype s A, B and C. J Med Virol 2006; 78: 1276–83.
- 7. Su C.-W. et al . The Influence of Hepat itis B Viral Loa d and Pre -S Delet ion Mutat ions on Post-Operat ive Rec urre nce of Hepatocell ular Carc inoma and the Tert iar y Pre ventive Effect s by Anti-Viral Therap y. // Plo S one. – 2013. – Vol . 8, N 6. – P. e66457.
- 8. Qu L. et al . Pre -S delet ion and co mple x mutat ions of hepat itis B virus relate d to young age hepatocell ular carc inoma in Qidong, China. // Plo S one. – 2013. – Vol . 8, N 3. – P. e59583
- 9. Okamoto, H., Imai M., Kameta ni M., Nakamura T., Mayumi M., Ge nomic hetero geneity of hepat itis B virus in 54- year -ol d woman who co ntracte d the infect ion though mater nofetal tra nsmission. Jpn J Exp Med 1987; 57: 231–36.
- 10. Girones, R, Miller RH, Mutat ion rate of the hepa dnavirus genome. Virolo gy 1989; 17 0: 595–97.
- 11. Nowak, M. A., Bonhoe ffer S., Hill A. M., Boe hme R., Thomas H. C., McDade H. Viral dynamics in hepat itis B virus infect ion. Proc Natl Acca d Sci USA 1996; 93: 4398–402.
- 12. Jardi, R, Rodriguez-Frias F, Schaper M, et al . Hepat it is B virus pol ymera se var iants assoc iate d with enteca vir drugs re sista nce in treat ment-naive pat ients. J Viral Hepat 2007; 14:835–40.