Аннотация
Список литературы
Настоящая работа посвящена изучению фармакодинамического потенциала комбинаций ТЦА амитриптилина со средствами из группы СИОЗС (эсциталопрамом, пароксетином и флувоксамином) в тесте «вынужденное плавание» (тест Порсольта(FST)) у мышей линии CBA. В экспериментах установлено синергичное антидепрессивное действие амитриптилина и эсциталопрама. Фармакодинамический потенциал комбинаций амитриптилина с пароксетином и флувоксамином не превышал таковой индивидуальных соединений.
Ключевые слова:
антидепрессант, комбинация, амитриптилин
Pharmacodynamic potential of combinations tricyclic antidepressant amitriptyline and selective serotonin re-uptake inhibitors
The purpose of present study was to estimate pharmacodynamic potential of combinations TCA amitriptyline and SSRIs (escitalopram, paroxetine and fluvoxamine) in forced swimming test (test Porsolt (FST)) carried out on male CBA mice. In experiments was determined synergic antidepressant effect of combination amitriptyline and escitalopram. Pharmacodynamic potential of combinations amitriptyline with paroxetine and fluvoxamine was comparable with such individual drugs.
Keywords
antidepressant, combination, amitriptyline
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