В.П. Сокольник
Республиканский научно-практический центр «Мать и дитя»
Дыхательная система образуется из эндодермы передней кишки. На протяжении морфогенеза лёгких эндодерма формирует древоподобную структуру эпителиальных канальцев, которые дифференцируются в дальнейшем в воздухоносные пути и альвеолы. Мезенхима даёт начало множественным компонентам лёгких, включая соединительную ткань, предшественники эндотелиальных клеток, гладкомышечные элементы, хрящи трахеи и бронхов, лимфатические сосуды и мезотелиальные клетки.
ключевые слова: лёгкие, SHH, TGFβ, FGF, Wnt
Molecular basis of several lung malformations
V. P. Sokolnik
The respiratory system arises from the foregut endoderm. During lung morphogenesis endoderm forms a tree-like structure of epithelial tubules and differentiates to produce airways and alveoli. The mesenchyme gives rise to multiple components of the lung, including its connective tissue, endothelial cell precursors, the smooth muscle, the tracheal-bronchial cartilage, the lymphatic, and the mesothelial cells.
keywords: lung, SHH, TGFβ, FGF, Wnt
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Поступила 15.09.2017 г.
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