А. Т. Быков, Т. Н. Маляренко
ГБУ ВПО «Кубанский государственный медицинский университет Минздрава России»
В представляемой обзорной статье основное внимание сфокусировано на деменции и болезни Альцгеймера (БА) в связи с интенсивным распространением во всём мире этих социально значимых нейродегенеративных заболеваний, что расценивается ВОЗ как быстро нарастающая эпидемия. Обсуждается концепция и механизмы взаимосвязи кишечной микробиоты с мозгом по двусторонней оси «кишечник-микробиота-мозг» в патогенезе деменции и БА.
ключевые слова: болезнь Альцгеймера, кишечная микробиота, профилактика, пробиотики
Gut microbiota brain axis and neurodegenerative diseases
A. T. Bykov, T. N. Malyarenko
In the focus of this review are dementia and Alzheimer's disease (AD) in connection with the intensive spread of these socially significant neurodegenerative diseases throughout the world, what is regarded by WHO as a rapidly growing epidemic. The concept and mechanisms of the rela-tionship of the intestinal microbiota with the brain on the bilateral axis "gut-microbiota-brain" in the pathogenesis of dementia and AD are discussed.
keywords: Alzheimer's disease, intestinal microbiota, prevention, probiotics
1. Alkasir, R., Li J., Li X. et al. Human gut microbiota: the links with dementia development // Protein Cell. - 2017. - Vol. 8. - Issue 2. - P. 90-102.
2. Barnard, N. D., Bush A.I., Ceccarelli A. et al. Dietary and lifestyle guidelines for the preven-tion of Alzheimer's disease // Neurobiol. Ageing. - 2014. - Vol. 35. - Suppl. 2. - S74-S78.
3. Bauer, K. C., Huus K. E., Finlay B. B. Microbes and the mind: emerging hallmarks of the gut microbiota-brain axis // Cell. Microbiol. - 2016. - Vol. 18. - P. 632-644.
4. Del Chierico, F., Vernocchi P., Dallapiccola B., Putignani L. Mediterranean dietand health: food effects on gut microbiota and disease control // Int. J. Mol. Sci. - 2014. - Vol. 15, № 7. - P. 11678-11699.
5. Dinan, T. G., Stilling R. M., Stanton C. etal. Collective unconscious: how gut microbiota shape human behavior // J. Psychiatr. Res. - 2015. - Vol. 63. - P. 1-9.
6. Erny, D., Prinz M. Microbiology: gut microbes augment neurodegeneration // Nature. - 2017. - Vol. 544. - P. 304-305.
7. Folch, J., Petrov D., Ettcheto M. et al. Current researches therapeutic strategies for Alz-heimer's disease treatment// Neural Plasticity. - 2016. - Vol. 2016. - Article ID 8501693. - 15 p.
8. Frolich, E. E., Farzi A., Mayerhofer R. etal. Cognitive impairment by antibiotic-induced gut disbiosis: analysis of gut microbiota- brain communication // Brain Behav. Immun. - 2016. - № 56. - P. 140-155.
9. Galley, J. D., Nelson M. C., Yu Z. et al. Exposure to a social stressor disrupts the community structure of the colonic mucosa- associated microbiota // BMC Microbiol. - 2014. - Vol. 14. - P. 189.
10. Gard, N., Luzzatto-Knaan Т., Melnik A. V. et al. Natural products as mediators of disease // Nat. Prod. Rep. - Jan. 2017. - Vol. 34, № 2. - P. 194-219.
11. Han, J.-Y., Han S.-H. Primary prevention of Alzheimer's disease: is it an attainable goal? // J. Korean Med. Sci. - 2014. - Vol. 29, № 7. - P. 886-892.
12. Hill, J. M., Lukiw W. J. Microbial-generated amyloids and Alzheimer's disease (AD) // Front. Aging Neurosci. - 2015. - Vol. 7. - 9 p.
13. Ни, N., Yu J.T., Tan L. etal. Nutrition and the risk of Alzheimer's disease // Biomed. Res. Int. - 2013. - Vol. 524, № 8. - P. 20.
14. Khan, F., Oloketuy S. F. A future perspective on neurodegenerative diseases: nasopharynge-al and gut microbiota // J. Appl. Microbiol. - 2017. - Vol. 122, Iss. 2. - P. 306-320.
15. Kraus, M., Getin M., Aricioglu F. The microbiota and gut-brain axis//JM00D. - 2016. - Vol. 6, № 3. - P. 172-179.
16. Liu, X., CaoS., Zhang X. Modulation of gut microbiota-brain axis by probiotics, prebiotics and diet // J. Agric. Food Chem. -
2015. - Vol. 63. - P. 885-7895.
17. Magnusson, K. R., Hauck L, Jeffrey В. M. etal. Relationship between diet-related changes in the gut microbiome and cognitive flexibility// Neurosci. - 2015. - Vol. 300. - P. 126-140.
18. Mattson, M. P. Late-onset dementia: a mosaic prototypical pathologies modifiable by diet and lifestyle // Nat. Aging Mech. Dis. - 2015. - № 1. - P. 15003.
19. Mayer, E. A., Knight R., Mazmaion S. K. et al. Gut microbes and the brain paradigm shift in neuroscience // J. Neurosci. - 2014. - Vol. 34. - P. 15490-15496.
20. Mayer, E. A., Tillisch K., Gupta A. Gut-brain axis and microbiota // J. Clin. Invest. - 2015. - Vol. 125, № 3. - P. 926-938.
21. Menezes, A. A., Montague M. G., Cumbers J. et al. Grand challenges in space synthetic biology // JRS Interface. - 2015. - № 12.
22. Montiel-Castro, A. J., Gonzalez-Cervantes R. M., Bravo- Ruiseco G., Pacheco-Lopez G. The microbiota-gut-brain axis: neurobehavioral correlates, health and sociality // Front. Integr. Neurosci. - 2013. - Vol. 7. - P. 70.
23. Moos, W. H., Faller D. V., Harrp D. N. et al. Microbiota and neurological disorders: a gut feeling // Biores. Open Access.-2016- Vol. 5, № 1. - P. 137-145
24. Morris, М. С., Tangney С. С., Wang U. et al. MIND diet associated with reduced incidence of Alzheimer's disease // Alsheimer's & Dement. - 2015.

25. Oriach, C. S., Robertson R. C., Stanton C. et al. Food for thought: the role of nutrition in the microbiota-gut-brain axis // Clin. Nutr. Exp. - 2016. - Vol. 6. - P. 25-38.
26. Otaegue-Arrazola, A., Amiano P., Elbusto A. et al. Diet, cognition, and Alzheimer's disease: food for thought // Eur. J. Nutr. - 2014. - Vol. 53. - P. 1-23.
27. Parashar, A., Udayabanu M. Gut microbiota regulates key modulators of social behavior // Eur. Neuropsychopharmacol. - 2016. - Vol. 26. - P. 78-91.
28. Prince, M., Wimo A., Guerchet M. et al. World Alzheimer Report 2015: The global impact of dementia. An analysis of prevalence, incidence, costs and trends // Alzheimer's Disease International. - London, 2015. - 92 p.
29. Quaglio, G., Brand H., Dario C. Fighting dementia in Europe: the time to act is now // Lancet Neurol. - 2016. - Vol. 15. - P. 452-454.
30. Rajpal, D. K., Brown J. R. Modulation ttfe human gut micro- biota as an emerging therapeutic paradigm // Sci. Progr. - 2013. - Vol. 96. - Pt. 3. - P. 224-236.
31. Sampson, T. R., Mazmanian S. K. Control of brain developcrobiome// Cell. Host. Microbe. -
32. Schmidt, С. Mental health: thinking from the gut // Nature. - 2015. - Vol. 518. - P. S12-S15.
33. Smith, A. D., Yaffe K. Dementia (including Alzheimer's disease) can be prevented: state-ment supported by international experts // J. Alzheimer's Dis. - 2014. - Vol. 38. - P. 699-703.
34. Swaminathan, A., Jicha G. A. Nutrition and prevention of Alzheimer's dementia // Frontiers in Aging Neurosci. - 2014. - 24 p. (http:/www.frontiersin.org/people/u/76286).
35. Tillisch, K. The effects of gut microbiota on CNS function in humanis // Gut. Microbes. - 2014. - Vol. 5, Iss. 3. - P. 404-410.
36. Umbrello, G., Esposito S. Microbiota and neurologic diseases: potential effects of probiotics // J. Transl. Med. - 2016. - Vol. 14. - P. 298-309.
37. Vandenplas, Y., Huys G., Daube G. Probiotics: an update // L. Pediatr. (Rio J.). - 2015. - Vol. 91. - P. 6-21.
38. Winblad, В., Amouyel P., Andrieu S. etal. Defeating Alzheimer's disease and other demen-tias: a priority for European science and society// Lancet Neurol. - 2016. - Vol. 15. - P. 455-532.
39. Zhou, L., Foster J. A. Psychobiotics and gut-brain axis: in the pursuit of happiness// Neuropsychiatr. Dis. Treat. - 2015. - Vol. 11. - P. 715-723.
40. Zuker, C.S. Food for brain // Cell. - 2015. - Vol. 161. - P. 9-11.
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