The authors present the clinical and epidemiological features of the disease of tic-based encephalitis among residents in Belarus. The main reservoirs of infection are described. We have demonstrated a clinical case of Central European tick-borne encephalitis. To solve the set tasks in this research, we used methods of epidemiological diagnostics and statistical research methods. According to the results obtained, the incidence of leptospirosis in Belarus for the studied interval (2012–2021) was unevenly distributed over the years. The maximum and minimum indicators differed 1.5 times. The average long-term incidence rate was 1.28 cases per 100 000 population. The analyzed period of time was characterized by a long-term epidemic trend towards an increase in the incidence. The risk group for tick-borne encephalitis was adults (95.0 ± 4.87 %). Most patients with tick-borne encephalitis in 2021 lived in the Moscow and Leninsky districts of Minsk (30.0 ± 10.25 % and 20.0 ± 8.94 %, p < 0.05). The efficiency rate of transmission of the tick-borne encephalitis virus during the bite of a virusophoric tick in 2021 was 1 case of TBE in 54 cases of tick bites.
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