The growing prevalence of multidrugresistant pathogens is a huge challenge for modern medicine, and this is especially true for patients in intensive care units (ICU). This article presents the results of monitoring the isolates of microorganisms and their resistance to antibiotics in the ICU of therapeutic and surgical profiles. As a result of the study, the following results were obtained: the greatest sensitivity of Klebsiellapneumoniae in therapeutic resuscitation is shown to colistin (100 %) and tigecycline (100 %), in surgical resuscitation – to extendedspectrum betalactamase (ESBL) (93.2 %) and tetracycline (58.9 %); Acinetobacter baumanii: in the therapeutic – to colistin (100 %), in the surgical – to colistin (100 %); Coagulasenegative staphylococci: in the therapeutic – to nitrofurantoin, linezolid, tigecycline, vancomycin (100 %); Staphylococcusaureus: in the therapeutic field – resistance to most of the drugs used, with the exception of benzylpenicillin; Pseudomonas aeruginosa: in the therapeutic – colistin (100 %), in the surgical – to colistin (100 %). This study emphasizes the importance of interdisciplinary interaction of hospital doctors, including ICUs with clinical bacteriologists and epidemiologists, as well as the role of timely correction of antibiotic therapy.
- 1. Тапальский, Д. В., Савченко О. И., Бонда Н. А. Распространенность Klebsiella pneumoniae – продуцентов карбапенемаз в Гомельской области Беларуси и их чувствительность к антибиотикам, комбинациям антибиотиков, дезинфектантам // Инфекция и иммунитет. – 2019. – № 9 – S. 671–679.
- 2. Alverdy, J. C., Burke D. Total parenteral nutrition: iatrogenic immuno-suppression // Nutrition. – 1992. – Vol. 8. – P. 359–365.
- 3. Bardi, T., Pintado V. et al. Nosocomial infections associated to COVID-19 in the intensive care unit: clinicalcharacteristics and outcome // Eur. J. Clin. Microbiol. In-fect Dis. – 2021. – Vol. 40, iss. 3. –P. 495–502.
- 4. Geffers, C., Zuschneid I. et al. Microbiological isolates associated with nosocomial infections in intensive care units: data of 274 intensive care units participating in the German Nosocomial Infections Surveillance System (KISS) // Anasthesiol In-tensivmed Notfallmed Schmerzther. – 2004. – Vol. 39, iss. 1. – P. 15–19.
- 5. Greathouse, K. C., Hall M. W. Critical Illness-Induced Immune Suppression: Current State of the Science // Am J Crit Care. – 2016. – Vol. 25, iss. 1. – P. 85–92.
- 6. Paterson, D. L. Restrictive antibiotic policies are appropriate in intensive care units // Crit Care Med. – 2003. – Supp. 1. – P. 25–28.
- 7. Remschmidt, Cornelius & Schneider et al. Surveillance of Antibiotic Use and Resistance in Intensive Care Units (SARI) // Deutsches Arzteblatt international. – 2017. – Vol. 114. – P. 858–865.
- 8. Ubeda, C., Taur Y. et al. Vancomycin-resistant Enterococcus domination of in-testinal microbiota is enabled by antibiotic treatment in mice and precedes blood-stream invasion in humans // Clin Invest. – 2010. – Vol. 120, iss. 12. – P. 4332–4341.