The article presents the results of their studieson the lean component in young patients with diabetes mellitus (CD) type 1. The study involved 95 patients with diabetes type 1 and 55 people in the control group. In young patients with diabetes type 1 were found gender differences in the amount and distribution of the lean component. The article presents the results of a quantitative assessment of muscular component in patients with diabetes type 1. There was a reduction appendicular muscle mass (AMM) in young men with diabetes type 1 compared with the control group. According to current concepts of the pathophysiology of diabetes type 1 describes possible changes in the muscle in this pathology.
- 1. World Health Organization. Prevention of diabetes mellitus. Report of a WHO Study Group. Geneva: World Health Organization; 1994. № 844.
- 2. Atkinson, M. A. Type 1 diabetes / M. A. Atkinson, G. S. Eisenbarth, A. W. Michels // Lancet. – 2014. – Vol. 1, № 4. – P. 69–82.
- 3. Patterson, C. Diabetes in the young – a global view and worldwide estimates of numbers of children with type 1 diabetes 1 // On behalf of the IDF Diabetes Atlas. – 2013.
- 4. Krause, M. P. Effects of type 1 diabetes mellitus on skeletal muscle: clinical observations and physiological mechanisms / M. P Krause, Riddell M. C., Hawke T. J. // Pediatric Diabetes. – 2010. doi: 10.1111/j.1399–1448.2010.00699.
- 5. The Official Positions of the International Society for Clinical Densitometry: Indications of Use and Reporting of DXA for Body Composition / D. L. Kendler [et al.] // Journal of Clinical Densitometry: Assessment & Management of Musculoskeletal Health. – 2013. – Vol. 16. – P. 496–507.
- 6. Burton, L. A. Optimal management of sarcopenia / L. A. Burton, D. Sumukadas // Clinical interventions in aging. – 2010. – № 5. – P. 217–228.
- 7. Inflammatory cytokine, growth factor and counter regulatory responses to exercise in children with type 1 diabetes and healthy controls / P. R. Galassetti [et al.] // Pediatr Diabetes. – 2006. –№ 7. – P. 16–24.
- 8. Critical evaluation of promising markers for sarcopenia /E. Cavalier [et al.] // Osteoporosis International. – 2015. – № 26. – P. ОС25.
- 9. Pedersen, K. Muscles, exercise and obesity: skeletal muscle as a secretory organ / K. Pedersen, A. Febbraio // Nature Reviews Endocrinology. – 2012. – № 8. – P. 457–465.