Повышение экспрессии мет-энкефалина в звездчатом ганглии человека после острого инфаркта миокарда

О.С. Сает, В.В. Руденок УО «Белорусский государственный медицинский университет»

2013 №1 | Оригинальные научные публикации

Аннотация

Список литературы

Методом непрямой иммуногистохимии исследована экспрессия мет-энкефалина (мет-ЭНК) в звездчатом ганглии человека в условиях острой ишемии миокарда. Показано значительное увеличение экспрессии мет-ЭНК в нейронах и волокнах исследованных узлов при остром инфаркте миокарда. Гипоксия, которая сопровождает острый инфаркт миокарда, является основным индуктором синтеза мет-ЭНК в нейронах звездчатого узла человека.

Ключевые слова:

мет-энкефалин, экспрессия, звездчатый узел, инфаркт миокарда

Up-regulation of met-enkephalin expression in human stellate ganglia after acute myocardial infarction

By the method of indirect immunohistochemistry the distribution patterns of met-enkephalin (met-ENK) expression in human stellate ganglia after acute myocardial infarction were investigated. Up regulation of met-ENK expression was revealed. We suggest that hypoxia which accompanies acute myocardial infarction is the main inducing factor for the synthesis of met-ENK. This is supposed to be a compensatory-adaptive reaction that helps to limit an ischemic injury of the heart.

Keywords

met-enkephalin, expression, ganglion stellatum, myocardial infarction

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