А.А. Троянов, Г.Г. Кондратенко, М.П. Потапнев, И.М. Храпов, С.И. Кривенко, О.В. Левандовская
УО «Белорусский государственный медицинский университет», УЗ «10-я городская клиническая больница» г. Минска, УЗ «9-я городская клиническая больница» г. Минска
Цель. Оценить эффективность клинического применения аутологичной плазмы, обогащенной растворимыми факторами тромбоцитов (ПОРФТ), при местном лечении диабетических язв кожи у пациентов с синдромом диабетической стопы (СДС).
ключевые слова: синдром диабетической стопы; аутологичная плазма, обогащенная растворимыми факторами тромбоцитов, заживление, кожные раны
Local therapy of diabetic foot ulcers by platelet-rich plasma
A.A. Troyanov, G.G. Kondratenko, M.P. Potapnev, I.M. Khrapau, S.I. Krivenko, O.V. Levandovskaya
Aim. To present examples of effective use of autologous platelet-rich plasma (PRP) for local therapy of diabetic foot ulcers in patients.
keywords: diabetic foot ulcer, autologous platelet-rich plasma, healing, cutaneous wounds
1. Дедов ИИ, Анциферов МБ, Галстян ГР, Токмакова АЮ. Синдром диабетической стопы. - М., ФДЦ МЗ РФ, 1998. - Т..4 [Dedov II, Ancipherov MB, Galstyan GR, Tokmackova AJu. Diabetic foot syndrome. – M. FDC MH RF; 1998.-V.4].
2. Laing P. The development and complications of diabetic foot ulcers. American J. Surgery. 1998; 176 (Suppl 2A): 11S-19S.
3. Jeffcoate WJ, Harding KG. Diabetic foot ulcers. Lancet. 2003; 361: 1545-1551. http://image.thelancet.com/extras/02art6190web.pdf
4. Steed DL, Attinger Ch, Colaizzi T et al. Guidelines for the treatment of diabetic ulcers// Wound Repair and Regeneration. 2006; 14: 680-692.
5. Tsourdi E, Barthel A, Rietzsch H, et al. Current aspects in the pathophysiology and treatment of chronic wounds in diabetes mellitus. BioMed Research International. Vol. 2013, art. ID 385641, 6 pages. http://dx.doi.org/10.1155/2013/385641
6. Villela DL, Santos VLCG. Evidence on the use of platelet-rich plasma for diabetic ulcer: A systemic review. Growth Factors. 2010; 28(2) 111-116. doi: 10.3109/08977190903468185
7. Picard F, Hersant B, Bosc R, MeningaudJ-P. The growing evidence for the use of platelet-rich plasma on diabetic chronic wounds: A review and proposal for a new standard care. Wound Repair and Regeneration. 2015; 23 (5): 638-643. doi :10.1111/wrr.12317
8. Приказ Министерства здравоохранения Республики Беларусь от 03.09.2012 г., № 981 «Об утверждении инструкции о порядке предоперационной заготовки аутологичной крови и ее компонентов» [The Order of Ministry of Public Health the Republic of Belarus # 981 on 03.09.2012 “ On approval the Instruction for the algorithm of autologous blood and blood components’ collection prior to operation”
9. Knighton DR, Ciresi KF, Fiegel VD, et al. Classification and treatment of chronic nonhealing wounds. Successful treatment with autologous platelet-derived wound healing factors (PDWHF). Annals of Surgery 1986; 204, 322-330.
10. Harm SK, Fung MK. Platelet-rich plasma injections: out of control and on the loose? Transfusion. 2015; 55 (7): 1596-1598.
11. Crovetti G, Martinelli G, Issi M et al. Platelet gel for healing cutaneous chronic wounds. Transfusion and Apheresis Science. 2004; 30:145–151. doi: 10.1016/j.transci.2004.01.004
12. Shan G-Q, Zhang Y-N, Ma J, et al. Evaluation of the Effects of Homologous Platelet Gel on Healing Lower Extremity Wounds in Patients With Diabetes. The International Journal of Low Extremity Wounds. 2013; 12(1): 22-29. Doi: 10.1177/1534734613477113
13. Kontopodis N, Tavlas E, Papadopoulos G, et al. Effectiveness of platelet-rich plasma to enhance healing of diabetic foot ulcers in patients with concomitant peripheral arterial disease and critical limb ischemia. The International Journal of Lower Extremity Wounds. 2015 March, 1- 7 doi: 10.1177/1534734615575829
14. Borzini P, Mazzucco P. Tissue regeneration and in loco administration of platelet derivatives: clinical outcome, heterogeneous products, and heterogeneity of the effector mechanisms. Transfusion. 2005; 45(11): 1759-1767. doi: 10.1111/j.1537-2995. 2005. 00600.x
15. Backly REI, Ulivi V, Tonachini L, et al. Platelet lysate induces in vitro wound healing of human keratinocytes associated with a strong proinflammatory response. Tissue Engineering Part A. 2011; 17(13-14): 1787-1800.doi: 10.1089/ten.tea.2010.0729
16. Потапнев МП, Арабей АА, Кондратенко ГГ и др. Растворимые факторы тромбоцитов и регенеративная медицина// Здравоохранение (Минск) .- 2014.- № 9.- С. 32-40 [Potapnev MP, Arabey AA, Kondratenko GG, et al. Soluble preparations of platelet growth factors and their medical implementation. Zdravookhranenie (Minsk). 2014; (9): 32-40.]
17. Renn T-Y, Kao Y-H, Wang C-C, Burnouf T. Anti-inflammatory effects of platelet biomaterials in a macrophage cellular model. Vox Sanguinus. 2015; 109(2); 138-147. Doi: 10.1111/ vox.12264
18. Mazzucco L, Medici D, Serra M, et al. The use of autologous platelet gel to treat difficult-to-heal wounds: a pilot study. Transfusion. 2004; 44 (7): 1013-1018.
Поступила 01.11.2017 г.
Формат файла: pdf (552.31 Кб)