А.В. Сокол, В.В. Руденок
УО «Белорусский государственный медицинский университет»
В работе представлены результаты иммуногистохимического исследования экспрессии нейропептида Y в вилочковой железы человека различных возрастных групп. Возрастные изменения экспрессии нейропептида Y в тимусе человека отражают уровень цитохимической зрелости и/или функциональной активности органа в определенный период онтогенеза.
ключевые слова: тимус человека, нейропептид Y, экспрессия
Age-dependent dynamic of neuropeptide Y expression in human thymus
A.V. Sokal, V. V. Roudenok
The results of immunohistochemical studies of expression of neuropeptide Y in the human thymus of different age groups are presented. Age-related changes in the expression of neuropeptide Y in the human thymus reflect of the cytochemical level of maturity and / or functional activity of the organ within period of ontogenesis.
keywords: human thymus, neuropeptide Y, expression
1. Bedoui, S, Kawamura N, Straub RH, Pabst R, Yamamura T, von Horsten S./ Relevance of neuropeptide Y for the neuroimmune crosstalk. // J Neuroimmunol. 2003 Jan;134(1¬2):1 – 11.
2. Bedoui, S, von Horsten S, Gebhardt T/ A role for neuropeptide Y (NPY) in phagocytosis: implications for innate and adaptive immunity. // Peptides. 2007 Feb;28(2):373 – 6
3. Bedoui, S, Kromer A, Gebhardt T, Jacobs R, Raber K, / Neuropeptide Y receptor¬specifically modulates human neutrophil function. // J. Neuroimmunol. 2008 Mar;195(1¬2):88 – 95.
4. Cavallotti, D, Artico M, Iannetti G, Cavallotti C Occurrence of adrenergic nerve fibers in human thymus during immune response. // 2002 Neurochem Int 40: 211 – 221
5. Colmers, WF, El Bahn B. «Neuropeptide Y and Epilepsy». Epilepsy 2003. – // Currents/American Epilepsy Society 2 (3): 53 – 8.
6. De la Fuente, M, Medina S, Del Rio M, Ferrandez MD, Hernanz A Effect of aging on the modulation of macrophage functions by neuropeptides. // Life Sci. 2000 Sep 15;67(17):2125 – 35.
7. De la Fuente, M, Del Rio M, Victor VM, Medina S / Neuropeptide Y effects on murine natural killer activity: changes with ageing and cAMP involvement. // Regul Pept. 2001 Sep 15;101(1¬3):73 – 9.
8. Dimitrijevic, M, Stanojevic S, Vujic V, Beck¬Sickinger A, von Horsten S (2005)Neuropeptide Y and its receptor subtypes specifically modulate rat peritoneal macrophage function in vitro: counter regulation through Y1 and Y2/5. // Regul. Pept. 124:163 – 172
9. Dimitrijevic, M, Stanojevic S, Mitic K, Kustrimovic N, Vujic V. The antiinflammatory effect of neuropeptide Y (NPY) in rats is dependent on dipeptidyl peptidase 4 (DP4) activity and age. // Peptides. 2008 Dec;29(12):2179¬87. Epub 2008 Sep
10. Du M, Butchi NB, Woods T, Morgan TW, Peterson KE. / Neuropeptide Y has a protective role during murine retrovirus¬induced neurological disease. // J Virol. 2010 Nov;84(21):11076 – 88. Epub 2010 Aug 11.
11. Ferreira, R, Xapelli S, Santos T, Silva AP, Cristovao A, Cortes L, Malva JO / Neuropeptide Y modulation of interleukin¬1 beta (IL¬1{beta})¬induced nitric oxide production in microglia. // J Neuroinflammation. 2011; 8: 169.
12. Herzog, H. Neuropeptide Y and energy homeostasis: insights from Y receptor knockout models. // Eur. J. Pharmacol. (2007) 480:21 – 29. Nature Medicine 13, 803 – 811
13. Groneberg, DA, Folkerts G, Peiser C, Chung KF, Fischer A Neuropeptide Y (NPY). // Pulm Pharmacol Ther. 2004;17(4):173 – 80.
14. Kranz, A, Kendall MD, von Gaudecker B. Studies on rat and human thymus to demonstrate immunoreactivity of calcitonin gene¬related peptide, tyrosine hydroxylase and neuropeptide Y. // J. Anat. (1997) 191, pp. 441±450.
15. Luhder, F, Lee DH, Gold R, Stegbauer J, Linker RA./ J Neuroimmunol. Small but powerful: short peptide hormones and their role in autoimmune inflammation. // Epub 2009 Sep 12.10;217(1¬2):1 – 7.
16. Medina, S, Del Rio M, Hernanz A, De la Fuente M / Age¬related changes in the neuropeptide Y effects on murine lymphoproliferation and interleukin¬2 production. // Peptides. 2000 Sep;21(9):1403 – 9.
17. Pons, J, Lee EW, Li L, Kitlinska J. Allen et al. Neuropeptide Y: multiple receptors and multiple roles in cardiovascular diseases. // Curr Opin Investig Drugs. 2004 Sep;5(9):957 – 62.
18. Prod’homme, T, Weber MS, Steinman L, Zamvil SS/ Trends Immunol. A neuropeptide in immune-mediated inflammation, Y?. // Epub 2006Apr;27(4):164 – 7.
19. Puerto, M, Guayerbas N, Alvarez P, De la Fuente M Modulation of neuropeptide Y and norepinephrine on several leucocyte functions in adult, old and very old mice. // J Neuroimmunol. 2005 Aug;165(1¬2):33 – 40.
20. Straub RH, Schaller T, Miller LE, von Horsten S, Jessop DS. Neuropeptide Y cotransmission with norepinephrine in the sympathetic nervemacrophage interplay. // J Neurochem 2000, 75: 2464 – 2471
21. Silva Alberto B., Danielle Aw and Donald B. Evolutionary conservation of neuropeptide expression in the thymus of different species // Palmer Blackwell Publishing Ltd, Immunology, 2006, 118, 131 – 140.
22. Wheway, J, Herzog H, Mackay F. NPY and receptors in immune and inflammatory diseases. // Curr Top Med Chem. 2007;7(17):1743 – 52.
23. Zukowska, Z, Pons J, Lee EW, Li L. Neuropeptide Y: a new mediator linking sympathetic nerves, blood vessels and immune system? // Can J Physiol Pharmacol. 2003 Feb;81(2):89 – 94.
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