А. Н. Нестерович, В. Г. Объедков
Республиканский научно-практический центр психического здоровья, УО «Белорусский государственный медицинский университет»
В статье приводится обзор литературы, посвященной генетическим исследованиям отдельных фенотипических паттернов шизофрении (т. н. «дименсий») – продуктивных симптомов, негативных симптомов и дезорганизации. Анализ наследуемости фенотипа в семьях, а также результаты молекулярно-генетических исследований указывают на то, что негативные симптомы шизофрении, а также дезорганизация наследуемы в большей степени, чем бред и галлюцинации, и могут быть детерминированы т. н. «генами-посредниками». Обнаружение новых «генов-посредников» шизофрении в контексте дименсиональной модели позволит лучше понять природу заболевания и выявить новые, потенциально модифицируемые механизмы патогенеза данного заболевания
ключевые слова: шизофрения, дименсиональная модель, дименсии, симптомы, клинические, генетика, генетические, гены
Clinical-genetic investigations of schizophrenia in the context of dimensional model
A. N. Nestsiarovich, V. G. Obyedkov
The article provides the overview of the literature concerning genetic investigations of single phenotypic traits of schizophrenia («dimensions») – positive symptoms, negative symptoms and disorganization. The analysis of phenotypic traits heritability in family and the results of the molecular genetic studies show that the negative symptoms of schizophrenia and disorganization are heritable to a greater extent compared to delusions and hallucinations and can be determined by the so-called «modifier-genes». Search for the new «modifier-genes» in the context of schizophrenia dimensional model may contribute to better understanding of disease nature and to discover new potentially modifiable mechanisms of its pathogenesis.
keywords: schizophrenia, dimensional model, dimensions, symptoms, clinical, genetics, genes
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